Doctoral Thesis

Synthesis of New Carbasugars from Quinic acid

Design and Synthesis of New Inhibitors of the Dehydroquinase Enzyme with Potential Antibiotic Activity

Synthesis of Selective Solid Supports of Cyclic trans-1,2-diols: Applications

Inhibitors of the Dehydroquinase Enzyme for the Development of New Antimicrobial Agents

Design, Synthesis and Biological Evaluation of Type II Dehydroquinase Inhibitors of Restricted Conformation

The inhibition of Type I and II Dehydroquinase Enzymes: A Strategy for the Development of New Antibiotics

Molecular Modeling Studies and its Application to the Discovery of New Antimicrobial Agents

Development of New Antimicrobials as Inhibitors of Shikimate Kinase and Type II Dehydroquinase Enzyme Involved in the Essential Amino Acids Biosynthesis

Inhibitors of the Shikimate Kinase Enzyme for the Treatment of Bacterial Infections: Design, Synthesis and Biological Evaluation

New Enzyme Inhibitors Involved in Virulence, Metabolism and Resistance Mechanism of Bacteria for the Treatment of Multi-Resistant Bacterial Infections

Control of Target and Ligand Conformation for the Development of Novel Antibiotics - Application to Shikimate Kinase Enzyme Inhibition 

New Methods of Clinical Diagnosis and Inhibitors of Bacterial Viability for the Identification and Control of Superbugs 

New Irreversible Inhibitors of beta-Lactamases for Recovering Antibiotics Efficiency against Superbugs

Novel Chromene and Imidazole Derivatives: Synthesis, Biological Evaluation and Computational Studies

Novel Approaches to Face the Challenge of Antibiotics Inefficiency Against Superbugs

Novel Antibacterial Therapies based on the inhibition of beta-Lactamases and the Shikimate Kinase Enzyme